The Effects of Aqueous Extract of Garcinia kola on Hematological Parameters and Lipid Profile in Female Sprague-Dawley Rats
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Abstract
Hematological parameters are veritable indicators of state of diseases and wellbeing of individuals. This study evaluated the effects of Garcinia kola on hematological parameters and lipid profile in sprague dawley rats. Eighteen adult female rats were used. These were divided into 3 groups; group A served as control, group B received Garcinia kola extract 0.5mg/kg orally, while group C received Garcinia kola extract 1.0 mg/kg of Garcinia kola. All groups were treated for 2 weeks. Comparately, there was no significant difference in the perked cell volume (PCV), hemoglobin (Hgb), red blood cell (RBC), mean corpuscular hemoglobin concentration (MCHC), triglyceride (TAG), total cholesterol, low density lipoprotein (LDL) and high density lipoprotein (HDLP) in groups treated with Garcinia kola compared with control. However there were significant decrease in WBC and significant increase in platelets, MCV and MCH in the treated groups compred with control. Based on the outcome of this study, aqueous extract of Garcinia kola has the potential of inreasing MCV and MCH but decrease WBC at a higher dose. The extract however had no significant effect on the lipid metabolism in spraque dawley rats.
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