Effect of Aqueous Leaf Extract of Justicia carnea on Hematological Parameters of Male Wistar Rats Exposed to Thioacetamide
http://www.doi.org/10.26538/tjpps/v2i2.2
Keywords:
Wistar rats, Thioacetamide, Silymarin, Justicia carnea, HematologyAbstract
This study evaluated the haematological potential of aqueous leaf extract of Justicia carnea against thioacetamide (TAA) induced toxicity in male Wistar rats. Thirty (30) male Wistar rats were randomly assigned into six (6) groups of five (5) animals each. Group A served as control. Group B received a single dose of TAA (300 mg/kg b.w.t) intraperitoneally, group C received TAA and 50 mg/kg b.w.t of silymarin while groups D, E, and F rats received TAA prior to administration of 200, 400, and 600 mg/kg b.w.t of the extract. The values of haemoglobin concentration (Hb), packed cell volume (PCV), and red blood cell count (RBC) were significantly (p ˂ 0.05) decreased, while a significant (p ˂ 0.05) increase in white blood cells (WBC) was observed in rats exposed to TAA. Treatment with the extract ameliorated the haematological alterations caused by TAA toxicity. These findings show the extract’s efficacy in ameliorating haematological alterations induced by TAA exposure and also validate its use in the folkloric management of haemolytic anemia.
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