<i>Datura Metel</i> Leaf Extracts Potential on Antioxidant Enzymes in Alloxan-Induced Diabetic Albino Rats
DOI:
https://doi.org/10.26538/tjpps/v3i9.3Keywords:
Environmental, Staphylococcus aureus, Salmonella spp., Shigella spp., Public waterAbstract
Public water systems must provide reliable, safe drinking water 24/7 to prevent contamination and illness. Regular testing for coliform bacteria is crucial to ensure clean, dependable water for the public. This study aimed to find coliforms in the public water supply in the Sokoto Metropolis. Eight (8) sterile bottles were used to collect eight (8) water samples, two samples from each of the four water treatment plants in Gagi, Arkilla, Wamakko, and Tashar Illela. As directed by the manufacturer, nutrient agar media, MacCkonkey, and Eosine methylene blue were produced. Standard procedures were followed for the isolates' verification and isolation. The result of this study has shown that the sample obtained from Gagi water production had the highest total mean count (25.9 × 106 CFU/ml). The sample obtained from Arkilla had the lowest total mean count of 4.7 × 105 CFU/ml, and the total coliform (MPN) recorded indicated that the samples obtained from Wamakko had the highest Most probable number (14/100ml). In contrast, the samples obtained from Arkilla had the lowest coliform count (6/100ml). The bacteria identified include Shigella spp (12.5%), Pseudomonas aeruginous (37.5%), Staphylococcus aureus (12.5%), Enterobacter spp (12.5%) and Salmonella spp (25%). Improvements to the environmental conditions in the research location and regular testing by the treatment facilities for coliforms are advised to create better water.
References
Regassa H, Sourirajan A, Kumar V, Pandey S, Kumar D, Dev K. A review of medicinal plants of the Himalayas with anti-proliferative activity for the treatment of various cancers. Cancers. 2022;14(16):3898.
World Health Organization. Global report on diabetes [Internet]. 2016 [cited 2024 Sep 12]. Available from:https://apps.who.int/iris/handle/10665/204871.
Kooti W, Farokhipour M, Asadzadeh Z, Ashtary-Larky D, Asadi-Samani M. The role of medicinal plants in the treatment of diabetes: A systematic review. Electron Physician. 2016;8(1):1832–1842.
Falodun A, Siraj R, Choudhary MI. GC-MS Insecticidal Leaf essential oil of P. staudtii Hutch and Dalz (Icacinaceae). Trop J. Pharm Res. 2009; 82:139-143.
Shehadeh MB, Suaifan GA, Abu-Odeh AM. Plants secondary metabolites as blood glucose-lowering molecules. Molecules. 2021;26(14):4333.
Usai R, Majoni S, Rwere F. Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review. Front. Pharmacol. 2022; 13:980819.
Shakya AK. Medicinal plants: Future source of new drugs. Int. J. Herb. Med. 2016;4(4):59-64.
Caperon L, Arjyal A, KC P, Kuikel J, Newell J, Peters R, Prestwich A, King R. Developing a socio-ecological model of dietary behaviour for people living with diabetes or high blood glucose levels in urban Nepal: A qualitative investigation. PloS one. 2019;14(3):e0214142.
Bessone F, Razori MV, Roma MG. Molecular pathways of nonalcoholic fatty liver disease development and progression. Cell. Mol. Life Sci. 2019;76:99-128.
Gordon C. Blood glucose monitoring in diabetes mellitus: current issues in Diabetes. Practice Nursing. 2020;31(Supp 3):3-11.
Federation ID. IDF Diabetes Atlas, Ninth Edition [Internet]. International Diabetes Federation; 2019. Available from: https://diabetesatlas.org.
Salehi B, Ata A, V. Anil Kumar N, Sharopov F, Ramírez-Alarcón K, Ruiz-Ortega A, Abdulmajid Ayatollahi S, Valere Tsouh Fokou P, Kobarfard F, Amiruddin Zakaria Z, Iriti M. Antidiabetic potential of medicinal plants and their active components. Biomolecules. 2019;9(10):551.
Halliwell B. Free radicals and antioxidants: Updating a personal view. Nutr Rev. 2012;70(5):257–265.
Forbes JM, Thorburn DR. Mitochondrial dysfunction in diabetic kidney disease. Nat. Rev. Nephrol. 2018;14(5):291-312.
Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: Friend or foe?. J. Sport Health Sci. 2020;9(5):415-425.
Cianciosi D, Forbes-Hernández TY, Afrin S, Gasparrini M, Reboredo-Rodriguez P, Manna PP, Zhang J, Bravo Lamas L, Martínez Flórez S, Agudo Toyos P, Quiles JL. Phenolic compounds in honey and their associated health benefits: A review. Molecules. 2018;23(9):2322.
Ighodaro OM, Adeosun AM, Akinloye OA. Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina. 2017;53(6):365-374.
Tran N, Pham B, Le L. Bioactive compounds in antidiabetic plants: From herbal medicine to modern drug discovery. Biol. 2020;9(9):252.
Kooti W, Moradi M, Akbari SA, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D. Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review. J Herb Med Pharmacol. 2015;4(1):1–9.
Afrisham R, Aberomand M, Ghaffari MA, Siahpoosh A, Jamalan M. Inhibitory effect of Heracleum persicum and Ziziphus jujuba on activity of alpha-amylase. J Bot. 2015; 2015:1–8.
Tahiya HA, Amira HS, Mohammad AH, Afaf MW, Qasim A. Comparative study of phytochemical screening, antioxidant, and antimicrobial capacities of fresh and dry leaves crude plant extracts of Datura metel L. J King Saud Univ Sci. 2014;26(3):237–243.
Twaij BM, Hasan MN. Bioactive secondary metabolites from plant sources: types, synthesis, and their therapeutic uses. Int. J. Plant Biol. 2022; 13(1):4-14.
Krishnan JU, George M, Ajesh G. Phytochemical status, antibacterial activity and antioxidant property of Datura metel L. Int J Cur Pharma Res. 2017;9(3):106-110.
Howard-Jones N. A CIOMS ethical code for animal experimentation. WHO Chron. 1985;39(2):51–56.
Dandagi PM. Rajiv Gandhi University of Health Sciences (India). ProQuest Dissertations & Theses Global; 2008.
Fawzi MM. Recent Advances to Evaluate Anti-Diabetic Medicinal Plants. In Medicinal Plants. 2012; 1:552-595. CRC Press.
Lorke D. A new approach to practical acute toxicity testing. Arch Toxicol. 1983;54(4):275–287.
Marklund S, Marklund G. Involvement of superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 1974;47(3):469–474.
Chance B, Maehly AC. Assay of catalase and peroxidases. In: Colowick SP, Kaplan NO, editors. Methods in Enzymology. Vol. II. Academic Press; 1955. p. 764–775.
Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978; 52:302–310.
Kanu KC, Ijeoma SN, Atiata O. Haematological, biochemical, and antioxidant changes in Wistar rats exposed to dichlorvos-based insecticide formulation used in southeast Nigeria. Toxics. 2016;4(4):28.
Kakimoto K, Kojima Y, Ishii K, Onoue K, Maeda H. The suppressive effect of gelatin-conjugated superoxide dismutase on disease development and severity of collagen-induced arthritis in mice. Clin Exp Immunol. 1993;94(2):241–246.
Ogino T, Inoue M, Ando Y, Awai M, Maeda H, Morino Y. Chemical modification of superoxide dismutase: Extension of plasma half-life of the enzyme through its reversible binding to circulating albumin. Int J Pept Protein Res. 1998;32(2):153–159.
Góth L. Catalase deficiency and type 2 diabetes. Diabetes Care. 2008;31(4):933–934.
Takemoto K, Tanaka M, Iwata H, Nishihara R, Ishihara K, Wang DH, et al. Low catalase activity in the blood is associated with the diabetes caused by alloxan. Clin Chim Acta. 2009; 407(1–2):43–46.
Bienert GP, Moller AL, Kristiansen KA, Schulz A, Moller IM, Schjoerring JK, et al. Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J Biol Chem. 2007; 282:1183–1192.
Pattar M, Kerur BS, Nirmala C. Determination of some minerals and trace elements in medicinal plants—Acalypha indica (L.), Datura metel (L.), and Tylophora indica—used in the treatment of asthma. European J Med Plants. 2018; 22(2), 1–11.
Gholamhoseinian A, Shahouzehi B, Mohammadi G. Trace elements content of some traditional plants used for the treatment of diabetes mellitus. Biointerface Res Appl Chem. 2020;10(5):6167-6173.
Okolie NP, Falodun A, Oluseyi D. Evaluation of the antioxidant activity of root extract of pepper fruit (Dennetia tripetala), and its potential for the inhibition of Lipid peroxidation. Afr J. Trad Compl and Altern Med. 2014; 11(3):221-227. Doi: 10.4314/ajtcam. v11i3.31
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Tropical Journal of Phytochemistry and Pharmaceutical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
