Inhibitory Effects of n-Hexane Extracts of <i>Sida acuta</i> and <i>Aspilia africana</i> Leaves on Platelet Aggregation
http://www.doi.org/10.26538/tjpps/v3i1.3
Keywords:
Inhibitory, Aspirin, aggregation, platelet, Aspilia africana, Sida acutaAbstract
Platelet hyperactivity significantly contributes to the pathogenesis of arterial thrombosis and atherosclerosis. The primary objective of this investigation was to assess the antiplatelet activity of the n-Hexane leaf extract of Sida acuta and Aspilia africana leaves using in vitro experiment. Standard analytical procedures were employed using UV-Vis spectrophotometric method. Three concentrations (0.5mg/ml, 2mg/ml and 4mg/ml) of Sida acuta and Aspilia africana leaf extracts were utilised. Aspirin (2mg/ml) and distilled water serving as positive and negative controls, respectively. Platelet aggregation was induced using 10% w/v Calcium chloride. The findings demonstrated that the n-Hexane leaf extract of Sida acuta exhibited a statistically significant antiplatelet activity of 55.00 ± 0.46, 55.45 ± 0.91 and 55.30 ± 0.95 while Aspilia africana extract displayed antiplatelet activities of 47.64±0.65, 51.41±1.13, and 51.74±0.29 at concentrations of 0.5mg/ml, 2.0mg/ml, and 4.0mg/ml, respectively, surpassing the antiplatelet activity of Aspirin, which was measured at 39.83%. The findings suggest that the extracts of the leaves of Sida acuta and Aspilia africana possess significant antiplatelet activity.
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