Effect of Ethanol and N-Hexane Combined Extracts of Selected Plants on Liver Enzymes in Wistar Rats
http://www.doi.org/10.26538/tjpps/v2i4.4
Keywords:
Medicinal plants, Liver enzymesAbstract
Medicinal plant are commonly used for the treatment of various diseases including liver disease. The ameliorative roles of these plants depends on their phytochemical contents, which is obtained based on the extracting solvent of choice. This study aims at determining the effect of ethanol and n-hexane combined extracts of selected plants on liver enzymes in wistar rats. A total of 18 wistar rats weighing 150 - 250 grams were separated into 3 groups of 6 rats each and 2 groups were administered with 200 mg/kg each of ethanol and n-hexane combined extracts for 7 days. Result showed that serum levels of alanine aminotransferase (118.50±5.99 and 102.17±3.73) and aspartate aminotransferase activities (162.83 ± 4.12 and 154.67 ± 2.16 IU/L) respectively were reduced more in ethanol extracts, while serum level of alkaline phosphatase (89.50±4.89 and 98.50±3.73) were reduced more in n-hexane treated group compared to control with (141.17±2.64) ALT, (173.17±2.13) AST and 108.17±2.32) ALP. This study revealed that administration of combined extracts of ethanol or n-hexane improved liver condition of wistar rats.
References
Okaiyeto K, Nwodo U, Mabinya L, Okoh A. A review on some medicinal plants with hepatoprotective effects. Pharmacogn. Rev. 2018; 12(24):186-199.
Omodamiro OD, Alaebo PO, Chikezie PC. Hepatotoxicity effects of methanol extract of Gmelina arborea leaves on liver enzymes marker in Wistar Rats. GSC Biol. Pharm Sci. 2021; 15(2):059-066.
Kalas MA, Chavez L, Leon M, Taweesedt PT, Surani S. Abnormal liver enzymes: A review for clinicians. World J Hepatol. 2021; 13(11):1688-1698.
Kim WT, Kim KM, Kang JS. Effect of Angelica gigas Nakai extract on hepatic damage in rats. Trop. J Pharm. Res. 2020; 19(5):1059-1064.
Hussain A, Ali AA, Ayaz S, Akram M, Ali A, Mehar P, Tariq Y. Hepatoprotective effects of various medicinal plants: A systematic review. J. Pharm. Phytochem. 2021; 10(3):109-121.
Seeff LB, Bonkovsky HL, Navarro VJ, Wang G. Herbal products and the liver: A review of adverse effects and mechanisms. J. Gastro. 2015; 148(3):517-532.
Clementine YF, Tar C, Aw C. Liver function tests (LFTs). Lab. 2010; 19:1-3.
Asadi-Samani M, Kafash-Farkhad N, Azimi N, Fasihi A, Alinia-Ahandani E, Rafieian-Kopaei M. Medicinal plants with hepatoprotective activity in Iranian folk medicine. Asian Pac. J Trop. Biomed. 2015; 5(2):146-157.
Kooti W, Ghasemiboroon M, Asadi-Samani M, Ahangarpoor A, Abadi A, Afrisham R, Dashti N. The effects of hydro-alcoholic extract of celery on lipid profile of rats fed a high fat diet. Adv. Environ. Biol. 2014; 8(9):325-330.
Foghis M, Bungau SG, Bungau AF, Vesa CM, Purza AL, Tarce AG, Tit DM, Pallag A, Behl T, ul Hassan SS, Radu AF. Plants-based medicine implication in the evolution of chronic liver diseases. Biomed. Pharm. 2023; 158:114207.
Bogavac-Stanojevic N, Kotur Stevuljevic J, Cerne D, Zupan J, Marc J, Vujic Z, Crevar-Sakac M, Sopic M, Munjas J, Radenkovic M, Jelic-Ivanovic Z. The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet. Pharm. Biol. 2018; 56(1):138-144.
El-Sayed YS, Lebda MA, Hassinin M, Neoman SA. Chicory (Cichorium intybus L.) root extract regulates the oxidative status and antioxidant gene transcripts in CCl4-induced Hepatotoxicity. PloS one. 2015; 10(3):e0121549.
Reitman S, Frankel S, Amer J. A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvate transaminases. Am J Clin. Pathol. 1957; 28(1):56-63.
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Tropical Journal of Phytochemistry and Pharmaceutical Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
