Effect of Ethanol and N-Hexane Combined Extracts of Selected Plants on Liver Enzymes in Wistar Rats
http://www.doi.org/10.26538/tjpps/v2i4.4
Keywords:
Medicinal plants, Liver enzymesAbstract
Medicinal plant are commonly used for the treatment of various diseases including liver disease. The ameliorative roles of these plants depends on their phytochemical contents, which is obtained based on the extracting solvent of choice. This study aims at determining the effect of ethanol and n-hexane combined extracts of selected plants on liver enzymes in wistar rats. A total of 18 wistar rats weighing 150 - 250 grams were separated into 3 groups of 6 rats each and 2 groups were administered with 200 mg/kg each of ethanol and n-hexane combined extracts for 7 days. Result showed that serum levels of alanine aminotransferase (118.50±5.99 and 102.17±3.73) and aspartate aminotransferase activities (162.83 ± 4.12 and 154.67 ± 2.16 IU/L) respectively were reduced more in ethanol extracts, while serum level of alkaline phosphatase (89.50±4.89 and 98.50±3.73) were reduced more in n-hexane treated group compared to control with (141.17±2.64) ALT, (173.17±2.13) AST and 108.17±2.32) ALP. This study revealed that administration of combined extracts of ethanol or n-hexane improved liver condition of wistar rats.
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