Effect of Lacatomtom Drink on Spatial Memory in Male Wistar Rat
DOI:
https://doi.org/10.26538/tjpps/v4i3.3Keywords:
opiodergic, brain, alternation, memory, LacatomtomAbstract
Lacatomtom is one of the emerging psychoactive substances abused by youths in Nigeria. It’s a mixture of tomtom candy and lacasera drink. The abuse of this substance has led to some pyschosocial deficit, this deficit are thought to be as a result of memory impairment. This study is therefore designed to look at the effect of lacatomtom on spatial memory in male Wistar rats. Twenty (20) Wistar rats weighing 120-150 g were randomly divided, five (5) each in a group of four (4). Group A served as control and received 1 mL/kg distilled water orally. Group B received 1 mL/kg of Lacatomtom (LTT) orally, meanwhile group C took 1 mL/kg Lacasera ( LC) orally. Group D received 1 mL/kg Lacawater (LW) orally. Animals were treated once, five minutes later, they were allowed to undergo the Y -maze test. Percentage alternations and number of entry was calculated for each group. Data were analysed using ANOVA at α 0.05. There was no significant difference in the arm entry in all the groups. Although the LTT group has the highest mean entry (14.8 ± 1.16) followed by the LC group (14.4 ± 1.21) and LW group (13.6 ± 0.93). The lowest entry observed was the control group (13.4 ± 1.21). There was a significant difference in the percentage alternation in the LTT group when compared to the control group.
The findings from this study suggests that Lacatomtom alters the spatial memory function of the brain in Wistar rats through mechanisms that may be dependent on the activation of opoidergic system in the brain.
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