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Red wine consumption has increased tremendously due to the apparent health benefits and pleasure derived from red wines. In the quest to search for alternative sources of raw material for wine production, the phytochemical and antioxidant properties of the cold and hot water extracts of Ficus capensis leaf as well as the wine produced from hot water extract of F. capensis leaf were evaluated. The qualitative screening of phytochemical constituents in cold and hot water extracts of F. capensis leaf revealed the presence of flavonoids, tannins, phenols, steroids, carbohydrates, proteins, amino acids, alkaloids and phytate. The quantitative phytochemical screening of the cold and hot water extracts as well as the wine extracts of F. capensis using HPLC method revealed the presence of important bioactive ingredients with the concentration of the phenolic and flavonoid compounds of F. capensis wine significantly (p<0.05) higher than the cold and hot water extracts. The wine extract exhibited significantly (p<0.5) decrease in the antioxidant activity against DPPH, nitric oxide, total antioxidant capacity and FRAP compared to the cold and hot water extracts. Moderate consumption of F. capensis wine would help to protect the organism against oxidative damage to lipids, proteins, and nucleic acids caused by the phenols in the drink. Moderate consumption of F. capensis wine would help to protect the organism against oxidative damage to nucleic acids lipids, and proteins caused by the phenols in the drink.
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Ebana RUB, Edet UO, Anosike KI, Etok CA, Kanu TO. Nutritional analysis and wine production potentials of Telfairia occidentalis (fluted pumpkin) leaves and Cucumis sativus L. (cucumber) using Baker’s and palm wine yeast strains. WNOFNS. 2019; 22:12-30.
Kantiyok BD, Mohammed SSD, Yabaya A. Fruit wine produced from pawpaw (Carica papaya) and watermelon (Citrullus vulgaris) using saccharomyces cerevisiae isolated from selected fermented foods. Sci World J. 2021;16(4):419–427.
Waheed D. Sadiya AD. Herbal wine formulation from fruits and vegetables wastes and peals. IJEAST. 2021; 5(9):129-133.
Yahia EM, Maldonado Celis ME, Svendsen M. The contribution of fruit and vegetable consumption to human health. Fruit and Vegetable Phytochemicals: Chem and Human Health, 2nd Edition. 2017; 11:1-52.
Chigozie VU, Okezie MU, Ajaegbu EE, Okoye FB, EsimoneCO. Bioactivities and HPLC analysis of secondary metabolites of a morphologically identified endophytic Aspergillus fungus isolated from Mangifera indica. Nat ProdRes. 2022; 36(22):5884-5888.
Roffler R, Randolph TW, Miller DA, Blanch HW, Prausnitz JM. Extractive bioconversions with nonaqueous solvents. In Extractive bioconversions. 2021; 133-172.
Mulani SA, Tamboli F A, More H N, Kolekar YS, Mali N. Formulation and evaluation of medicated guava (Psidium guajava L.) wine using Saccharomyces crevices Var. HAU 1. Indian J Pharm Pharmacol. 2021; 8(2):168-170.
Nardi T. Microbial resources as a tool for enhancing sustainability in winemaking. Microorganisms. 2020; 8(4):507.
Lopes ACA, Eda SH, Andrade RP, Amorim JC, Duarte WF. New alcoholic fermented beverages—potentials and challenges. Fermented Beverages. 2019: 577-603.
Schaefer R, Olsen J, Thach L. Exploratory wine consumer behavior in a transitional market: The case of Poland. Wine Econ. 2018; 7(1):54-64.
Nwachukwu C, Hieu MV, Chládková, H, Fadeyi O. Strategy implementation drivers in correlation with strategic performance. J Mark Manag. 2019; 17(1): 19-38.
Ohana-Levi N, Netzer Y. Long-Term Trends of Global Wine Market. Agriculture, 2023; 13(1):224-248
Ofoedu CE, Ofoedu EO, Chacha JS, Owuamanam CI, Efekalam IS, Awuchi CG. Comparative Evaluation of Physicochemical, Antioxidant, and Sensory Properties of Red Wine as Markers of Its Quality and Authenticity. Int J Food Sci. 2022; 2022.
Kevwe, B. E., Samuel, O. A., Omolola, T. F and Oluyemisi, F. K. Ficus capensis Thumb. (Moraceae): Review of Its Ethnomedicinal Uses, Pharmacological Activities and Phytochemical Constituents. Arch Curr Res Int. 2018; 12(13):1-7
Pawlos Z, Chandravanshi BS, Yohannes W, Embiale A. Levels of selected metals in Ficus sur Forssk fruit and soil of the plant grown in different parts of Ethiopia. SINET: Ethiop J Health Sci. 2021; 44(1):1-12.
Ezeigwe OC, Okpala CO, Ogana J, Akonam NE, Aziagba BO, Nnadi NN, Anekwe OJ, Nwobodo VOG. Comparative Phytochemical and Nutritional Profiles of F. capensis and Cnidoscolus aconitifolius Leaves. IJRIAS. 2020; 5(1):16-21.
Nawaz H, Waheed R, Nawaz M. Phytochemical composition, antioxidant potential, and medicinal significance of Ficus. Modern Fruit Industry. 2020; 1(20).
Van Vuuren S, Frank L. Southern African medicinal plants used as blood purifiers. J ethnopharmacol. 2020; 249:112434.
Adebayo-Tayo R, Odeniyi A. Phytochemicals screening and Microbial inhibitory. Activities of Ficus capensis. Afr J Biomed Res. 2012; 15:35-40
Eluka P, Nwodo F, Akah P. Onyeto C. Anti-ulcerogenic and antioxidant properties of the aqueous leaf extract of F. capensis in Wistar albino rats. MRJMMS. 2015; 3(1): 022-026
Uzoekwe NM, Mohammed JJ. Phytochemical, proximate and Mineral contents of leaves and back of Ficus capensis. J Appl Sci Environ Manag. 2015; 19(4):633-637.
Ayinde BA, Owolabi OJ. Effect of the aqueous extract of F. capensis Thumb (Moraceae) leaf on gastrointestinal motility. J Pharmacogn and Phytotherapy. 2009;1(3):031-035
Daikwo OA, Tende JA, Okey S, Eze ED, Isa AS. The Effect of Aqueous Extract of Leaf of Ficus capensis Thunb (Moraceae) on in vivo Leukocyte Mobilization in Wistar Rats. Br J Pharmacol Toxicol. 2012; 3(3):110-114
Adaji MU, Dauda JA, Ameh EM, Ocheme GW, Aaron PE. Evaluation of Antioxidant Potency, Antimicrobial Activity and Phytochemical Screening of Ficus capensis Leaves (Cape Fig). Int J Glob Sustain. 2020; 6(3):8-8.
Sahira KB, Cathrine L. General techniques involved in phytochemical analysis. Int J Adv Res Chem Sci. 2015; 2(4):25-35.
Evans WC. Trease and Evans pharmacognosy. 1997. 14th edn., W.B Saunders, London, UK
Osuntokun OT, Oluwafoise BO. Phytochemical screening of ten Nigerian medicinal plants. Int J Multidiscip Res Dev. 2015; 2(4): 390-396.
Singleton, V. and Rossi, J. Colorimetry of Total Phenolic Compounds with Phosphomolybdic-Phosphotungstic Acid Reagents. Am J Enol Vitic. 1965; 16:144-158.
Miller GL. Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar. J Anal Chem. 1959; 31: 426-428.
Jia ZS, Tang MC, Wu JM. The Determination of Flavonoid Contents in Mulberry and Their Scavenging Effects on Superoxide Radicals. Food Chem. 1999; 64: 555-559.
Shamsa F, Hamidreza M, Rouhollah G. Mohammadreza V. Spectrophotometric determination of total alkaloids in some Iranian medicinal plants. Thai J Pharm Sci. 2008; 32:17-20
Wilcox JR, Premachandra, GS. Young K.A. and Raboy V. Isolation of high seed inorganic P, low-phytate soybean mutants. Crop Sci. 2000; 40:1601-1605
Manzocco, L, Anese M, Nicoli MC. Antioxidant properties of tea extracts as affected by processing. LWT. 1998; 31 (7-8):694-698.
Marcocci l, Marguire JJ, Droyy-lefaiz MT, Packer L. The nitric oxide scavenging properties of ginkgo biloba extract. Biochem Biophys Res Commun.1994; 201:748-755.
Benzie FF, Strain JJ. Ferric reducing/antioxidant power assay: Direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Meth Enzymol. 1996; 299:15-27
Prieto P, Pineda M, Aguilar M. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Anal Biochem.1999; 269(2):337-41.
Pawaskar SM, Sasangan KC. Preliminary phytochemical and invitro-antimicrobial analysis of Annona squamosa linn. leaf extract. J Pharm Sci Res. 2017; 9(5):618.
Shadrach I, Banji A, Adebayo O. Nutraceutical potential of ripe and unripe plantain peels: A comparative study. Chem Int. 2020; 6(2):83-90.
Singayina, BE Keswet, LA Asiya, L Osaji, MJ. Assesment of Nurtritional Analysis of Bombax buonopozense Found in Adamawa and Taraba States, Nigeria (Red Flowered Silk Cotton Tree). Sciences. 2022; 11(1):7-11.
Ngozi P Okolie, Falodun A and Oluseyi Davids. Evaluation of the antioxidant activity of root extract of pepper fruit (Dennetia tripetala), and its potential for the inhibition of Lipid peroxidation. Afri J Trad Complem and Altern Med 2014; 11(3):221-227.
Egharevba E, Chukwuemeke-Nwani P, Eboh U, Okoye E, Bolanle IO, Oseghale IO, Imieje VO, Erharuyi O, Falodun A. Antioxidant and Hypoglycaemic Potentials of the Leaf Extracts of Stachytarphyta jamaicensis (Verbenaceae). Trop J Nat Prod Res. 2019; 3(5):170-174.
Jucá MM, Cysne Filho FMS, de Almeida JC, Mesquita DDS, Barriga JRDM, Dias KCF, Vasconcelos SMM. Flavonoids: biological activities and therapeutic potential. Nat Prod Res.2020; 34(5):692-705.
Ajai N, Elavarasan S, Priya AK, Akash S, Annie TJ, Bhuvana G. Experimental study on partial replacement of cement by metakaolin and GGBS. Mater Today: Proc. 2021; 37:3527-3530.
Kumar SS, Arya M, Nagbhushan P, Giridhar P, Shetty NP, Yannam SK, Mahadevappa P. Evaluation of various drying methods on bioactives, ascorbic acid and antioxidant potentials of Talinum triangulare L. foliage. Plant Foods Hum Nutr. 2020; 75(2):283-291.
Okechukwu VU, Amaefule AI, Omokpariola DO, Umeh TC, Oze NR, Omokpariola PL. The Impact of Processing Procedures on the Proximate and Phytochemical Composition of Unripe Musa paradisiaca (Plantain). Eur J Sustain Dev Res. 2022; 6(3):188.
Kaur P, Purewal SS, Sandhu KS, Kaur M, Salar RK. Millets: A cereal grain with potent antioxidants and health benefits. J Food Meas Charact. 2019; 13(1):793-806.
Zahrani NAA, El-Shishtawy RM, Asiri AM. Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry. A review. Eur J Med Chem. 2020; 7
Egbune EO, Ezedom T, Anigboro AA, Aganbi E, Amata AI, Tonukari NJ. Antioxidants and antigenotoxic properties of Rhizopus oligosporus fermented cassava (Manihot esculenta Crantz). Afr J Biochem Res. 2022; 16(3):39-46
Odion EE, Falodun A and Adelusi SA. Total flavonoid, Total Phenolic and antioxidant potential of root bark extract and fractions of from Cola rostrata (Sterculiaceae) K. Schum. University of Benin. J Sci Tech. 2013; 1(2): 38-42.
Oluwajuyitan TD, Ijarotimi OS, Fagbemi TN. Plantain‐based dough meal: Nutritional property, antioxidant activity and dyslipidemia ameliorating potential in high‐fat‐induced rats. Food Frontiers. 2022; 3(3):489-504.
Seun AF, Oboh G, Oyeleye SI, Aline BA. Aqueous extract from F. capensis leaves inhibits key enzymes linked to erectile dysfunction and prevent oxidative stress in rats' penile tissue. NFSJ. 2016; 4:15-21.
Shodehinde SA, Adefegha SA, Oboh G, Oyeleye SI, Olasehinde TA, Nwanna EE, Adebayo BC. Boligon AA. Phenolic composition and evaluation of methanol and aqueous extracts of bitter gourd (Momordica charantia L) leaves on Angiotensin-l-converting enzyme and some prooxidant – induced Lipid peroxidation invitro. J Evid Based Complementary Altern. 2016; 21(4):67-76.
Otitoju GTO, Nwamarah JU, Otitoju O, Odoh EC and Iyeghe LU. Phytochemical composition of some underlisted green leafy vegetables in Nsukka urban L.G.A. of Enugu state. J Biodivers Environ Sci. 2014; 4(4):208-217.
Wilfred OO, Philip FU, Emamanuel OE, Sampson C, Nwabuko. Comparative phytochemical, antioxidant and antimicrobial properties of Ficus capensis, Aristolochia ringens, Albizia zygia and Lannae welwitschii. J pharm sci. 2017; 16(2):147-157.
Chizoruo IF, Onyekachi IB, Odinaka NP, Chinyelu EM. Phytochemical, FTIR and elemental studies of African Mistlotoe (Viscun album) leaves on Cola nitida from SouthEastern Nigeria. World Scientific News. 2019; 132:84-97.
Sampaio BL, Costa FBD. Influence of abiotic environmental factors on the main constituents of the volatile oils of Tithonia diversifolia. Rev Bras Farmacogn. 2018; 28(2):135-144.
Türkmen, M Kara, M Maral, H. Soylu S. Determination of chemical component of essential oil of Origanum dubium plants grown at different altitudes and antifungal activity against Sclerotinia sclerotiorum. J Food Process Preserv. 2022; 46(6):15787.
Walia A, Gupta AK, Sharma V. Role of bioactive compounds in human health. Acta Sci. Med. Sci. 2019;3(9):25-33.
Lukas S, Jiri M, Lenka S, Mojmir B, Irena H, Tunde J, Rene K, Eva S, Jiri S. Contribution of Red Wine Consumption to Human Health Protection. Molecule. 2018; 23(7): 1684.
Alugoju P, Periyasamy L, Dyavaiah M. Quercetin enhances stress resistance in Saccharomyces cerevisiae tel1 mutant cells to different stressors. J Food Sci Technol. 2018; 55(4):1455-1466.
Leri M, Scuto M, Ontario ML, Calabrese V, Calabrese EJ, Bucciantini M, and Stefani M. Healthy effects of plant polyphenols: molecular mechanisms. Int J Mol Sci. 2020; 21(4):1250.
Ewa N, Irena S, Maciej G, Andrzej M, Piotr S, Joanna P. Małgorzata F. Oxidative Stress in Neurodegenerative Diseases. Mol Neurobiol. 2016; 53;4094–4125
Pérez-Torres I, Castrejón-Téllez V, Soto ME, Rubio-Ruiz ME, Manzano-Pech L, Guarner-Lans V. Oxidative stress,plant natural antioxidants, and obesity. Int J Mol Sci. 2021; 22(4):1786.
Medrano-Padial C, Puerto M, Richard T, Cantos-Villar E, Pichardo S. Protection and reversion role of a pure stilbene extract from grapevine shoot and its major compounds against an induced oxidative stress. J Funct Foods. 2021; 79:104393.
Jesus M, Romaní A, Mata F, Domingues L. Current options in the valorisation of vine pruning residue for the production of biofuels, biopolymers, antioxidants, and bio-composites following the concept of biorefinery: a review. Polymers. 2022; 14(9):1640.
Naveed M, Hejazi V, Abbas M, Kamboh AA, Khan G J, Shumzaid M, XiaoHui Z. Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomed Pharmacother. 2018; 97:67-74.
Wang G, Song X, Zhu L, Li Q, Zheng F, Geng X, Sun B. A flavoromics strategy for the differentiation of different types of Baijiu according to the non-volatile organic acids. Food Chem. 2022; 374: 131641.
Bohn T, Desmarchelier C, El SN, Keijer J, van Schothorst E, Rühl R, Borel P. β-Carotene in the human body: metabolic bioactivation pathways–from digestion to tissue distribution and excretion. Proc Nutr Soc. 2019; 78(1):68-87.
Mota A, Pinto J, Fartouce I, Correia MJ, Costa R, Carvalho R, Oliveira AA. Chemical profile and antioxidant potential of four table grape (Vitis vinifera) cultivars grown in Douro region, Portugal. Cienc Tec Vitivinic. 2018; 33(2):125-135.
Zhang Z, Zhang J, Fan L, Kilmartin PA. Degradation of cyanidin-3-O-glucoside induced by antioxidant compounds in model Chinese bayberry wine: Kinetic studies and mechanisms. Food Chem. 2022; 373:131426.
Muhammad Abdul Kadar NN, Ahmad F, Teoh SL, Yahaya MF. Caffeic acid on metabolic syndrome: a review. Molecules. 2021; 26(18):5490.
Zhu L, Qi X, Bai J, Sun X, Hou H. The mechanism of molecular cross-linking against nonenzymatic degradation in the body wall of ready-to-eat sea cucumber. Food Chem. 2022; 373:131359
Agunloye OM, Oboh G. Caffeic acid and chlorogenic acid: Evaluation of antioxidant effect and inhibition of key enzymes linked with hypertension. J Food Biochem. 2018; 42(4):12541.
Dias IH, Milic I, Heiss C, Ademowo OS, Polidori MC, Devitt A, Griffiths HR. Inflammation, lipid (per) oxidation, and redox regulation. Antioxid Redox Signal. 2020; 33(3):166-190.
Esra AS, Betul AY. Effect of Taraxacum officinale L. ethanol extract against kidney injuries induced by paracetamol in rats. GSC Biol Pharm Sci. 2022; 21(1):144-151.
Odunola OA. Assessment of in-vitro antioxidant activities and genotoxicity in E. coli of ethanol extracts of Vitellaria paradoxa (Gaertn. F). Arch Med. 2019; 7(1):13-20.
Tekos F, Makri S, Skaperda Z. V Patouna, A Terizi, K Kyriazis, ID, Demetrios K. Assessment of antioxidant and antimutagenic properties of red and white wine extracts in vitro. Metabolites. 2021; 11(7):436
Singh S, Gupta A, Verma S. In vitro antioxidant activities of two medicinal plants on the basis of DPPH free radical scavenging activity. Ann Romanian Soc Cell Biol. 2021; 13:4807-11.
Doris A. Rosemary IU. Phytochemical, Antimicrobial and Free Radical Scavenging Activity of Ficus capensis Thunb Leaves. J Complement Altern Med Res. 2016; 1(4):1-7
Ehimwenma SO, Osarieme TO. Invitro antioxidant activity and phytochemical screening of methanol extracts of Ficus capensis and Dacryodes edulis leaves. JPB. 2014; 11(2):66-75.
Ján M, Peter C, Ivana M, Daniel B, Radoslav K. Changes of Selected Antioxidant Parameters of Red Wines during Maturation. Czech J Food Sci. 2016; 34 (4):356–361.
Gabriele M, Gerardi C, Lucejko JJ, Longo V, Pucci L, Domenici V. Effects of low sulfur dioxide concentrations on bioactive compounds and antioxidant properties of Aglianico red wine. Food Chem. 2018; 245:1105-1112.
Đorđević NO, Todorović N, Novaković IT, Pezo LL, Pejin B, Maraš gV., and Pajović, S. B. Antioxidant activity of selected polyphenolics in yeast cells: The case study of Montenegrin Merlot wine. Molecules. 2018; 23(8):1971